Michelle

Staff Product Development Engineer

Biomedical scientist and engineer with a PhD in Biomedical Sciences and Project Management Professional (PMP) certification. Over a decade of experience spanning academic research, postdoctoral study, and medical device product development. Specializes in tissue engineering, regenerative medicine, and FDA regulatory submissions for Class II medical devices.

Skills

Medical Device Regulation (21 CFR Part 820)FDA 510(k) SubmissionsISO 10993 BiocompatibilityISO 13485 Quality SystemsISO 14971 Risk ManagementProject Management (PMP)Tissue EngineeringStem Cell BiologyDesign Verification & ValidationTechnical WritingCross-functional Team LeadershipExperimental Design & Analysis

Experience

Staff Product Development Engineer

ACell, Inc. (now Integra Lifesciences)

April 2022 – Present

Columbia, MD

  • ·Lead medical device development projects from concept through FDA approval and commercial launch.
  • ·Manage cross-functional project teams and participate in Franchise teams.
  • ·Prepare Special and Traditional 510(k) submissions to the FDA.
  • ·Prepare risk assessments, evaluation plans, gap analyses, and reports in compliance with ISO 10993 and ISO 14971.
  • ·Design experiments, validate test methods, and qualify equipment and processes including packaging validation, design verification and validation, shelf life studies, and pre-clinical studies.
  • ·Test products to ISO 10993 (Biocompatibility), ISO 11137 (Sterilization), and IEC 62366 (Usability) standards.
  • ·Author protocols, reports, and standard operating procedures.
  • ·Prepare project budgets, timelines, and business cases.

Senior Product Development Engineer

ACell, Inc.

January 2020 – April 2022

Columbia, MD

  • ·Advanced medical device projects through the product development lifecycle.
  • ·Led design control activities including voice of customer, test method validation, and regulatory documentation.
  • ·Contributed to 510(k) submissions and biocompatibility evaluation plans.

Product Development Engineer

ACell, Inc.

June 2017 – December 2019

Columbia, MD

  • ·Executed design verification and validation studies for Class II medical devices.
  • ·Authored technical reports and standard operating procedures.
  • ·Supported FDA regulatory submissions and pre-clinical study coordination.

Postdoctoral Associate

University of Pittsburgh — McGowan Institute for Regenerative Medicine

June 2015 – May 2017

Pittsburgh, PA

  • ·Conducted research in the Laboratory of Stephen F. Badylak on extracellular matrix (ECM) bioscaffolds and regenerative medicine.
  • ·Served as liaison and project lead for four commercial collaborations and multiple independent research projects.
  • ·Investigated wound healing, innate immunity, macrophage characterization and polarization, and bone regeneration models.
  • ·Wrote original research papers, reviews, book chapters, materials transfer agreements, and grants.
  • ·Mentored PhD students, undergraduate researchers, and high school students.
  • ·Presented research at national conferences.

Research Assistant

Tulane University School of Medicine — Center for Stem Cell Research

August 2010 – May 2015

New Orleans, LA

  • ·Conducted doctoral research in the Laboratory of Bruce A. Bunnell on lung tissue engineering, lung bioreactors, and stem and endothelial cell biology.
  • ·Managed project teams and cross-functional collaborations.
  • ·Mentored medical students, PhD students, and supervised individual research projects.
  • ·Wrote original research papers and reviews; presented at internal and external conferences.
  • ·Research areas included organ/tissue decellularization and recellularization (liver and trachea), bioreactor design, iPSC polarization and culture, hepatocyte isolation, and fluorescence-activated cell sorting.

Teaching Assistant

Tulane University

August 2010 – December 2011

New Orleans, LA

  • ·Taught Molecular Biology Laboratory and graded for Biochemistry.

Summer Research Fellow

Tulane National Primate Research Center

June 2009 – August 2009

New Orleans, LA

  • ·Investigated the use of mesenchymal stem cells as a treatment for globoid cell leukodystrophy.
  • ·Presented research at the 2009 TNPRC Summer Research Symposium.

Education

PhD in Biomedical Sciences (GPA 4.0)

Tulane University School of Medicine

New Orleans, LA

August 2010 – May 2015

Doctoral thesis on lung tissue engineering, lung bioreactors, and stem and endothelial cell biology. Selected honors: Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award (APS, 2011); Tulane Health Sciences Research Days Award — Stem Cell Research and Regenerative Medicine (2012); Tulane Health Sciences Research Days Award — Excellence in Research and Presentation (2013).

Bachelor of Science in Biochemistry (GPA 3.9) — Summa Cum Laude with Honors

Florida State University

Tallahassee, FL

August 2007 – May 2010

Member of Golden Key International Honour Society, National Society of Collegiate Scholars, and Phi Eta Sigma National Honors Society.

Certifications

Project Management Professional (PMP)

Project Management Institute

Medical Device Project and Team Manager

Industry Certification

Design Control Requirements — Integrating the Quality System Regulation

AAMI

Biocompatibility of Medical Devices (ISO 10993)

NAMSA Laboratories

Publications

Re-endothelialization of Rat Lung Through Passive, Gravity-driven Seeding of Segment-Specific Pulmonary Endothelial Cells

Scarritt ME, Pashos NC, Motherwell JM, Eagle ZR, Burkett BJ, Gregory AN, Mostany R, Weiss DJ, Alvarez DF, Bunnell BA.

Journal of Tissue Engineering and Regenerative Medicine·2018·10/1002/term.2382

Matrix-bound Nanovesicles Recapitulate Extracellular Matrix Effects on Macrophage Phenotype

Huleihel L, Bartolacci JG, Dziki JL, Vorobyov T, Arnold B, Scarritt ME, Molina CP, LoPresti ST, Brown BN, Naranjo JD, and Badylak SF.

Tissue Engineering Part A·2017·10.1089/ten.TEA.2017.0102

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

Dziki JL, Huleihel L, Scarritt ME, Badylak SF.

Tissue Engineering Part A·2017·10.1089/ten.TEA.2016.0538

The Influence of Extracellular RNA on Cell Behavior in Health, Disease and Regeneration

Huleihel L, Scarritt ME*, Badylak SF. (*contributed equally)

Current Pathobiology Reports·2017·10.1007/s40139-017-0121-2

Macrophage phenotype in response to ECM bioscaffolds

Huleihel L, Dziki JL, Bartolacci JG, Rausch T, Scarritt ME, Cramer MC, Vorobyov T, LoPresti ST, Swinehart IT, White LJ, Brown BN, and Badylak SF.

Seminars in Immunology·2017·10.1016/j.smim.2017.04.004

Characterization of an Acellular Scaffold for a Tissue Engineering Approach to the Nipple-Areolar Complex Reconstruction

Pashos NC, Scarritt ME, Eagle ZR, Gimble JM, Chaffin AE, Bunnell BA.

Cells Tissues Organs·2017·10/1159/000455070

Regenerative Medicine: Lessons from Mother Nature

Naranjo JD, Scarritt ME, Huleihel L, Ravindra A, Torres CM, and Badylak SF.

Regenerative Medicine·2016·10.2217/rme-2016-0110

Organ engineering: Promise, progress, and prospective

Scarritt M, Badylak SF.

The Biochemist·2016

A Review of Cellularization Strategies for Tissue Engineering of Whole Organs

Scarritt ME, Pashos NC, Bunnell BA.

Frontiers in Bioengineering and Biotechnology·2015·10.3389/fbioe.2015.00043

Hypertensive Rat Lungs Retain Hallmarks of Vascular Disease Upon Decellularization but Support the Growth of Mesenchymal Stem Cells

Scarritt ME, Bonvillain RW, Burkett BJ, Wang G, Glotser EY, Zhang Q, Sammarco MC, Betancourt AM, Sullivan DE, Bunnell BA.

Tissue Engineering Part A·2014·10.1089/ten/TEA.2013.0438

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-Organ Bioreactor

Bonvillain RW, Scarritt ME, Pashos NC, Mayeux JP, Meshberger CL, Betancourt AM, Sullivan DE, Bunnell BA.

Journal of Visualized Experiments·2013·10.3791/50825

A Nonhuman Primate Model of Lung Regeneration: Detergent-Mediated Decellularization and Initial In Vitro Recellularization with Mesenchymal Stem Cells

Bonvillain RW, Danchuk S, Sullivan DE, Betancourt AM, Semon JA, Eagle ME, Mayeux JP, Gregory AN, Wang G, Townley IK, Borg ZD, Weiss DJ, Bunnell BA.

Tissue Engineering Part A·2012·10.1089/ten/tea.2011.0594

Battling Inflammation in Acute Lung Injury and Acute Respiratory Distress Syndrome: Stem Cell-Based Therapy Targeting the Root Cause of Acute Lung

Sullivan DE, Bonvillain RW, Zhang S, Eagle ME, Danchuk S, Bunnell BA.

Journal of Pulmonary and Respiratory Medicine·2011·10.4172/2161-105X.S2-001

Mesenchymal-lineage stem cells have pronounced anti-inflammatory effects in the twitcher mouse model of Krabbe's disease

Ripoll C, Flaat M, Eiermann J, Perkins J, Trygg C, Scruggs B, McCants M, Leonard H, Lin A, Zhang S, Eagle M, Alvarez X, Li Y, Li S, Gimble J, Bunnell B.

Stem Cells·2011·10.1002/stem.555